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Launch of our new product : Clostridium difficile

Clostridium difficile is one of the most prevalent nosocomial pathogen mainly affecting patients after antibiotic treatment. Toxinogenic strains of C. difficile cause infections from mild diarrhoea to pseudomembranous colitis, potentially leading to death. The tissue-damaging enterotoxin (Toxin A) and the cytotoxin (Toxin B) produced by toxinogenic strains of C.difficile are responsible for the disease.

Due to the lack of sensitivity of toxins A&B rapid diagnostic tests, recommended algorithms for testing for toxinogenic C. difficile infection require detection of the C. difficile GDH as antigenic marker in stool as a first step. This test should have the highest possible sensitivity to ensure that no infected patients are missed.

Coris BioConcept Clostridium K-SeT allows the specific detection of C.difficile‘s GDH in stool specimen. There is a 100% concordance for detection of GDH between the Clostridium K-SeT test and an ELISA assay.  Moreover, another study shows a 100% NPV regarding culture.  This evaluation has been conducted in a reference lab in Brussels and compared to a test regarded as the reference test in the EC and the US.

This study has shown that the Coris test performs better than the reference one. Results have been submitted at the ICAAC meeting in San Francisco this year.

2 comments for “Launch of our new product : Clostridium difficile”

  1. My friend has just been diagnosed with C Difficile…my question…is this contagious?

  2. Dear Georgia James,

    This is not so the presence of the bacterium, which is important. It is the production of toxins by this bacterium.
    As the bacteria overgrow they release toxins that attack the lining of the intestines, causing a condition called Clostridium difficile colitis.
    Although C. diff occasionally causes problems in healthy people, it is most likely to affect patients in hospitals or long-term care facilities.

    Once a person has C. diff infection, the infection can spread to others. C. diff spores are shed in the feces and can live on dry surfaces for a long time. A person who touches one of those surfaces can pick up the infection.

    Fortunately, infection can be prevented. If you are in contact with someone who has the infection, good hygiene is vital. The following precautions can help keep you — and others — safe:
    Wash your hands with soap and water frequently.
    Clean surfaces in bathrooms and kitchens regularly with chlorine bleach-based products.
    Wash soiled clothing with detergent and chlorine bleach.
    If you are visiting someone in a health care facility, wash your hands before and after your visit. If you use the restroom, wash your hands well to remove possible C. diff spores.

    Don’t hesitate to contact us for any further information you might need.

    Best regards,

    Coris BioConcept

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