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OXA-23 K-SeT: the new solution to detect OXA-23 carbapenemase


The global spread of carbapenem-resistant Acinetobacter spp., and particularly A. baumanii, in healthcare settings causes a major threat to patient survival. Worldwide, drug-resistant Acinetobacter spp. are responsible for serious nosocomial outbreaks, mostly in intensive care units. Even though different resistance mechanisms have been described, production of Amber Class D oxacillinases OXA-23-like hydrolysis enzymes is the most frequent acquired mechanism.

Fast and accurate detection of OXA-23-producing strains remains challenging at the laboratory level. Specific identification of oxacillinase-expressing Acinetobacter requires genotypic molecular assays that remain expensive and not commercially available. Immunochromatography lateral flow tests are however cost-effective and convenient to detect drug hydrolyzing enzymes.

Today, a large panel of lateral flow tests to detect carbapenemase-expressing Enterobacteriacea, named “RESIST”, is commercialized by the Belgian company Coris BioConcept. In order to fulfill the unmet need for fast and reliable detection of drug-resistant Acinetobacter, Coris BioConcept developed a new lateral flow assay, “OXA-23 K-SeT”, for the specific identification of OXA-23-mediated carbapenem-resistant in Acinetobacter spp. from a single colony.

With results available in less than 15 minutes, this easy-to-use and instrument-free rapid test represents the first phenotypic, specific and non-molecular confirmatory assay for OXA-23 detection. It will expand the RESIST range of products already adopted nowadays by routine and reference laboratories worldwide, offering an additional tool to ensure the successful treatment of patients and prevent the spread of carbapenemase-producing bacteria in healthcare settings.


OXA-23 K-SeT

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