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Products  >  Human-Field  >  RESIST-3 O.K.N.  >  Science

RESIST-3 O.K.N. - Science


• OXA-48-, KPC- & NDM-type carbapenemase-producing organism detection.

G L Vanstone, E Wey, R Smith, D Mack and I Balakrishnan.

Article is presented on website of  Pathology in Practice magazine and at the Institute of Biomedical Science congress, 2017 24-27 Sept in Birmingham, UK.

Multidrug resistance exhibited by a range of microorganisms is a growing problem, a prime example being that resulting from carbapenemase production.
Here, Gemma Vanstone and colleagues assess the value of the RESIST-3 O.K.N. lateral-flow immunochromatography assay.


• P4884 – Evaluation of a new multiplex immunochromatographic assay OKN K-SeT for the rapid detection of OXA-48, KPC and NDM carbapenemases from cultured bacteria.

Y. Glupczynski, A. Jousset, S. Evrard, R. Bonnin, TD Huang, L. Dortet, P. Bogaerts and T. Naas.

27th European Congress of Clinical Microbiology and Infectious Diseases, Infectious Diseases April 22 – 25, 2017



• Rapid Detection of Carbapenemases in Enterobacteriaceae: Evaluation of the RESIST-3 O.K.N (OXA-48, KPC, NDM) Multiplexed Lateral Flow Assay.

Wareham DW and Momin MHFA.

J. Clin. Microbiol. Accepted manuscript posted online 1 February 2017 doi:10.1128/JCM.02471-16

The identification, treatment and control of carbapenem resistant Enterobacteriaceae (CRE) infections are a major challenge for healthcare institutions and diagnostic laboratories worldwide.…


• Rapid Detection of OXA-48, KPC and NDM-type carbapenemase producing organisms (CPOs) using the RESIST-3 O.K.N. assay.

G. L. Vanstone, E. Wey, R. Smith, D. Mack, I. Balakrishnan



• Prospective evaluation of the OKN K-SeT assay, a new multiplex immunochromatographic test for the rapid detection of OXA-48-like, KPC and NDM carbapenemases.

Glupczynski Y, Jousset A, Evrard S, Bonnin RA, Huang TD, Dortet L, Bogaerts P, Naas T.

J Antimicrob Chemother. 2017 Mar 22



There is an urgent need for accurate and fast diagnostic tests capable of identifying carbapenemase producers. Here, we assessed the performance of a new multiplex lateral flow assay (OKN K -SeT) for the rapid detection of OXA-48-like, KPC and NDM carbapenemase-producing Enterobacteriaceae from culture colonies.


Two hundred collection isolates with characterized β-lactamase content and 183 non-duplicate consecutive isolates referred to two National Reference Centres over a 2 month period in 2016 were used to evaluate the OKN K -SeT assay.


The assay correctly detected all 42 OXA-48-like-, 27 KPC- and 30 NDM-producing isolates from the collection panel, including 7 isolates that co-produced NDM and OXA-181 carbapenemases. No cross-reactivity was observed with non-targeted carbapenemases ( n  =   41) or with non-carbapenemase producers ( n  =   60). Prospectively, all OXA-48-like ( n  =   69), KPC ( n  =   9) and NDM ( n  =   19) carbapenemase-producing Enterobacteriaceae isolates were correctly detected, while 11 carbapenemase producers not targeted by the assay went undetected [VIM ( n  =   8) and OXA-23/OXA-58-like ( n  =   3)]. Overall, the sensitivity and specificity of the assay were 100%.


The OKN assay is efficient, rapid and easy to implement in the workflow of a clinical microbiology laboratory for the confirmation of OXA-48, NDM and KPC carbapenemases. This test represents a powerful diagnostic tool as it enables the rapid detection of the most clinically important carbapenemases without the need for more costly and less frequently available molecular assays.

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